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What We Don’t Know

One big hurdle to the knowledge about the keto diet’s impact on humans is that many of the benefits – helping reduce inflammation in the brain, improving outcomes after brain injury and extending lifespan – have only been found in studies in mice.

Far fewer clinical studies have been done in humans outside of seizure prevention since ketosis is a difficult state to maintain; avoiding carbs, including fruit, bread, legumes, and the occasional office birthday cake isn’t feasible for many people in the long run.

Without peer-reviewed clinical trials, many of the benefits remain anecdotal. For instance, Weiss himself has been on a low-carb high-fat (though not strictly ketogenic) diet for more than six months, and claims he does feel much better. But he’s clear about what he knows and what he doesn’t. He’s lost weight and his borderline pre-diabetes is gone.

“I think I feel great,” he said. But that might be because he’s eating less processed food, sleeping better, or enjoying compliments on his new physique.

As to the most exotic claims from health and diet gurus – such as keto diet’s resulting in euphoria, cognitive boosts, and improvements in anything from kidney function to cancer treatment – “We just don’t have the data on that yet,” said Weiss.

The researchers agree that the diet itself isn’t inherently dangerous. But, cautions Weiss, “If you have any medical condition, if you take any medicine at all – there are lots of things that change how medicines work in our bodies, and nutrition is definitely one of them. If you’re making a real change in your nutrition, you really should talk to your doctor.”

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